Analyzing the Electrochemical Interaction of the Angiogenesis Inhibitor Batimastat by Surface-Enhanced Raman Spectroscopy

This is the first work to describe vibrational properties of anticancer drug batimastat (BB-94) as an inhibitor extracellular matrix metalloproteinase with a broad spectrum activity. In addition, adsorption this molecule onto silver roughened electrode surface using surface-enhanced Raman spectroscopy (SERS) was studied. research provides complete account influence applied potential and excitation wavelengths at molecule-metal interface. Although assignment becomes more difficult size increases, we performed density functional theory (DFT) B3LYP/6-31G(d,p) level calculate molecular geometry in equilibrium state frequencies clarify nature modes. The greatest amplification SERS signal occurs for −0.3 V 532 nm line shifts moves near-infrared laser 785 nm. conclusion that mercaptothiophene part one amide groups interact metal surface. results charge transfer resonant process molecule, which has been found by analyzing profiles. Finally, there possibility formation different species or complexes on could contribute whole observed spectra.